№02Brief2026-05-30

Neoantigen vaccines accelerate across glioblastoma pancreatic and Lynch indications

Clinical activity in personalized neoantigen vaccines is accelerating across glioblastoma, pancreatic, and Lynch syndrome indications, with ZSky Biotech advancing a DC vaccine into Phase II and Nous-209 targeting cancer interception.

On the methodological front, new AI models like tcrLM and PhysicoGPTCR are improving TCR-antigen binding prediction and generative design, while circRNA platforms demonstrate synergistic potential with checkpoint blockade.

1new story29 in context

ClinicalyesterdayNew

Personalized Neoantigen Vaccine Generates Immune Activity, Encouraging Survival Signals in GBM - Docwire News

Docwire News reports that a personalized neoantigen vaccine has generated immune activity and encouraging survival signals in glioblastoma (GBM). This signal reinforces the clinical viability of personalized approaches in aggressive CNS tumors, though specific sponsor or trial phase details are not provided in the summary.

news · yesterday · Docwire News

Catching up29

Relevant work from earlier we're still surfacing — not today's news.

QUILT-2.025 NANT Neoepitope Yeast Vaccine (YE-NEO-001): Adjuvant Immunotherapy Using a Personalized Neoepitope Yeast-Based Vaccine To Induce T-Cell Responses In Subjects W/ Previously Treated Cancers.clinicaltrials · 3 weeks agoNew

Neoepitope-based Personalized DNA Vaccine Approach in Pediatric Patients With Recurrent Central Nervous System Tumorsclinicaltrials · 3 weeks agoNew

Neoantigen Vaccines in Pancreatic Cancer in the Window Prior to Surgeryclinicaltrials · 3 weeks agoNew

A DNAJB1-PRKACA Fusion Kinase Peptide Vaccine Combined With Glutamine Antagonist DRP-104, Nivolumab, and Ipilimumab in Patients With Advanced Stage Fibrolamellar Carcinoma (FLC)clinicaltrials · 3 weeks agoNew

GNOS-PV02 Personalized Neoantigen Vaccine, INO-9012 and Pembrolizumab in Subjects With Advanced HCCclinicaltrials · 5 weeks agoNew

Personalized NeoAntigen Cancer Vaccine w RT Plus Pembrolizumab for Patients With Newly Diagnosed GBMclinicaltrials · 6 weeks agoNew

KRAS Neoantigen Nanovaccine as Adjuvant Therapy for Colorectal Cancer/Pancreatic Cancerclinicaltrials · Apr 2026New

Russia’s FMBA approves second personalized cancer vaccine Oncorna - Новости GxPnews · Apr 2026New

Personalized neoantigen cancer vaccines: Why clinical benefit remains inconsistent - ScienceDirect.comnews · Apr 2026New

Treatment of Advanced Endocrine Tumor With Iindividualized mRNA Neoantigen Vaccine (mRNA-0523-L001)clinicaltrials · Apr 2026New

A Clinical Study of Personalized Self-DC Vaccine Targeting Neoantigen in Treatment of Advanced Solid Tumorclinicaltrials · Apr 2026New

Personalized Dendritic Cell Vaccine Pilot for High Risk TNBC After Neoadjuvant Therapyclinicaltrials · Apr 2026New

A circRNA neoantigen vaccine elicits potent antitumor immunity and synergizes with checkpoint blockade in melanoma.europepmc · Mar 2026New

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumorsclinicaltrials · Mar 2026New

The promises and challenges of neoantigen cancer vaccines - Naturenews · Mar 2026New

A Vaccine (Neoantigen-Targeted ppDC) for the Treatment of H3 G34-mutant Diffuse Hemispheric Gliomaclinicaltrials · Feb 2026New

XH001 Combination With Immunocheckpoint Inhibitor and Chemotherapy for Patients With Resected Pancreatic Cancerclinicaltrials · Feb 2026New

Evaluation of the Safety, Tolerability and Efficacy of iNeo-Vac-R01, an Individualized mRNA Therapeutic Technology Based on Tumor Neoantigens, for Adjuvant Treatment in Patients With Biliary Malignant Tumors After Radical Resectionclinicaltrials · Feb 2026New

Neoantigen-Pulsed Autologous Dendritic Cell Vaccine Combined With Temozolomide for Newly Diagnosed Glioblastomaclinicaltrials · Jan 2026New

Multi-strategy embedded framework for neoantigen vaccine maturation - Naturenews · Jan 2026New

New Paper Alert: Nous-209 Neoantigen Vaccine for Cancer Interception in Lynch Syndrome - Oncodailynews · Jan 2026New

Nous-209 neoantigen vaccine for cancer prevention in Lynch syndrome carriers: a phase 1b/2 trial - Naturenews · Jan 2026New

neoantigens enable selective and potent cross-HLA immunotherapy - Naturenews · Dec 2025New

Advances in the development of personalized neoantigen therapies - Rockefeller University Pressnews · Dec 2025New

RNA sequencing enables neoantigen discovery and vaccine validation in breast and lung cancer - Frontiersnews · Oct 2025New

Physicochemically Informed Dual-Conditioned Generative Model of T-Cell Receptor Variable Regions for Cellular Therapyarxiv · Oct 2025New

DapPep: Domain Adaptive Peptide-agnostic Learning for Universal T-cell Receptor-antigen Binding Affinity Predictionarxiv · Nov 2024New

tcrLM: a lightweight protein language model for predicting T cell receptor and epitope binding specificityarxiv · Jun 2024New

Contact map dependence of a T cell receptor binding repertoirearxiv · Dec 2021New