Clinical3 days agoNew
Specific killing of Ewing sarcoma by TCR-T cells targeting public neogene-encoded antigens
Researchers identified neogenes (Ew_NGs) induced by the EWSR1::FLI1 fusion in Ewing sarcoma, which present peptides on HLA-I complexes. CD8+ T cells specific to these public antigens killed EwS cells in an HLA-I restricted manner, a process dependent on both the fusion and the neogene expression. Transduced TCR-T cells replicated this cytotoxicity in vivo without off-target or allogeneic activation, suggesting a viable cell therapy for relapsed/resistant cases.