AI / MethodsyesterdayNew
IgGM2: An All-Atom Foundation Model for Adaptive Immune Receptor Design
IgGM2 is a new all-atom foundation model for adaptive immune receptor design that jointly generates CDR residue identities and full-atom structures. Unlike modular pipelines, it uses a structure-to-design strategy to allow framework geometry to adapt to designed CDRs without separate inverse folding. This unified approach aims to improve accuracy in modeling the coupled variation of sequence, conformation, and binding geometry for antibodies and TCRs.