AI / MethodstodayNew
Tumor infiltrating lymphocytes in glioblastoma: immunobiology and translational implications.
A review of glioblastoma immunobiology highlights a critical disconnect between murine models and human tumors: patient GBM is enriched for clonally expanded granzyme K+ T cells, whereas standard mouse models show exhausted T cells. This distinction suggests that current preclinical models may misrepresent the targetable neoantigen landscape. The authors argue that harnessing tumor-selective T cells via neoantigen vaccines or adoptive transfer requires a refined focus on these specific human TIL profiles.