Brief · 2026-06-05

Moderna Merck show durable five year melanoma survival

Moderna and Merck report durable five-year survival data for their personalized melanoma vaccine combined with KEYTRUDA, reinforcing the clinical viability of neoantigen vaccines in late-stage settings.

Meanwhile, methodological advances include an in silico-in vitro workflow for KRAS G12D-targeting antibodies and new insights into HNSCC immune phenotypes linking neoantigen clonality to T-cell exhaustion.

Clinical2 days agoNew

Moderna and Merck Report Five-Year Melanoma Data Showing Durable Benefit of Personalized Cancer Vaccine With KEYTRUDA - bio-itworld.com

Moderna and Merck have released five-year follow-up data for their personalized cancer vaccine candidate combined with KEYTRUDA in melanoma, demonstrating durable clinical benefit. This long-term efficacy signal is critical for validating the neoantigen vaccine platform's ability to sustain immune responses and improve survival outcomes in advanced disease.

news · 2 days ago · bio-itworld.com

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AI / Methods2 days agoNew

Discovery of TCR-like antibodies to the KRAS G12D neoantigen via in silico-in vitro workflow.

Researchers developed an integrated in silico-in vitro workflow to generate high-affinity, selective antibodies targeting the KRAS G12D neoantigen presented by HLA-C*08:02. The method combines in silico docking and CDR design with yeast surface-display selection, yielding antibodies with no off-target reactivity that can be reformatted as CARs or bispecific T-cell engagers for therapeutic use.

europepmc · 2 days ago · Ahn S, Oh TS, Suh S, Jeon JY, Lah S, Ryu K, Choi S, Kim H, Lee EG, Lee H, Lee J, Kim Y, Ki

AI / Methods2 days agoNew

Inverse relationship between neoantigen clonality and T-cell activity reveals distinct immune phenotypes in HNSCC.

Analysis of 527 HNSCC tumors reveals an inverse relationship between neoantigen clonality and T-cell activity, challenging the hypothesis that clonal neoantigens drive exhaustion. Using pVACseq and MHCflurry, the study found that clonal neoantigens correlate with reduced T-cell infiltration and activation signatures, suggesting distinct immune phenotypes that may impact vaccine target selection.

europepmc · 2 days ago · Saravi B, Singh DD, Schorn L, Lommen J, Schrader F, Wilkat M, Vollmer A, Vollmer M, Hartma