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Evaxion EVX-01 Shows 75% Response Rate in Melanoma

Evaxion advances its EVX-01 melanoma program with three-year efficacy data at ESMO 2026, highlighting durability and standalone potential.The Manila Times

On the methodological front, Paean offers significant speedups for transcriptome quantification via GPU-CPU parallelization, while new research explores NMD inhibition to preserve neoantigen expression and chemically synthesized RNA oligonucleotides to accelerate vaccine manufacturing timelines.PubMedPubMedPubMed

4new stories1 in context
ClinicaltodayNew

Evaxion to present three-year clinical efficacy data for personalized cancer vaccine EVX-01 at the ESMO Congress 2026 - The Manila Times

The data stems from a one-year extension of the phase 2 trial evaluating EVX-01 in patients with advanced melanoma (skin cancer). In the third year, patients received EVX-01 as stand-alone therapy, meaning the data will offer insight into the vaccine’s effect also when not admini…

news · today · The Manila Times

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AI / MethodsyesterdayNew

Nonsense-mediated mRNA decay as a gatekeeper of neoantigen expression: Bridging RNA surveillance and tumor immunotherapy.

The nonsense-mediated mRNA decay (NMD) is a highly conserved post-transcriptional mRNA screening system that is vital in keeping cellular integrity by targeting aberrant mRNAs harboring premature termination codons (PTCs) for degradation. Although traditionally considered as a sy…

europepmc · yesterday · Majumder S, Panigrahi GK, Sahoo A.
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AI / MethodsyesterdayNew

IVT-free, chemically synthesized protein-encoding RNA oligonucleotides for rapid production of personalized cancer vaccines.

Personalized mRNA neoantigen vaccines demonstrate great potential in cancer therapy, but their customization typically requires more than three months, risking the loss of the optimal therapeutic window for patients. This delay is primarily due to the reliance of current mRNA vac…

europepmc · yesterday · Pan Q, Zhang C, Wang X, Yin J, She S, Chen X, Dong R, Wu Y, Liao X, Wang Y, Yan H, Kou H,

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Relevant work from earlier we're still surfacing — not today's news.