TOPICS / TUMOR TYPE

Lynch syndrome

Lynch syndrome — a hereditary mismatch-repair-deficient predisposition whose shared frameshift neoantigens enable preventive ('interceptive') vaccines.

Topic2 items2026-08-11 – 2026-10-14

Tumor types

Melanoma88 Head & neck cancer10 Liver cancer (HCC)10 Ovarian cancer9 Glioblastoma8 Colorectal cancer5 Pancreatic cancer5 Breast cancer3 Lung cancer (NSCLC)2 Lynch syndrome2 Kidney cancer (RCC)2 Gastric cancer1

AI / Methods

Spatiotemporal profiling of T cell repertoires in Lynch syndrome reveals convergent immune responses through neoplastic progression

Surveillance of individuals with Lynch syndrome (LS), who are carriers of heterozygous inactivating mismatch repair (MMR) gene mutations that predispose to colorectal cancer, enables the study of tumour-immune coevolution during tumour initiation. Somatic loss of MMR activity in …

biorxiv · brief 2026-10-14 · published 2026-10-12

Commercial

Nouscom’s NOUS-209 viral vector neoantigen vaccine earns FDA Fast Track for Lynch Syndrome cancer prevention - AllSci

Nouscom, a clinical-stage biotech headquartered in Basel, Switzerland, announced receipt of US FDA Fast Track Designation for NOUS-209, a viral vector-based, off-the-shelf neoantigen cancer vaccine, for the prevention of Lynch Syndrome (LS)-associated cancers in carriers with gen…

news · brief 2026-08-11 · published 2026-06-01